Oxymorphone & Concomitant Use with Cytochrome P450 (CYP) Enzyme Inhibitors

Basic Details
Status
Complete
Last Updated
Wednesday, September 4, 2019
Health Outcome(s)
concomitant use with cytochrome P450 (CYP) enzyme inhibitors
Purpose
Drug Use
Regulatory Determination / Use

Drug-drug interactions are an important clinical concern. In a March 2017 Advisory Committee, briefing documents raised the possibility that oxymorphone may be used for a particular niche - patients taking multiple medications - because its metabolism did not involve the hepatic cytochrome P450 system. FDA conducted an analysis to assess whether oxymorphone’s metabolism influenced prescriber practices. Results revealed that similar proportions of patients were dispensed oxymorphone combined with other CYP modifiers relative to reference products, suggesting that drug metabolism differences did not influence prescribing behavior.