Concomitant Use of Opioid Analgesics and Cytochrome P450 (CYP) Inhibitors and Inducers

Basic Details
Date Posted
Thursday, February 1, 2018
Status
Complete
Medical Product
CYP inducer
CYP inhibitor
oxycodone
oxymorphone
Description

The goal of this query was to estimate the proportion of incident oxycodone and oxymorphone users concomitantly using a selection of cytochrome P450 (CYP) enzyme inhibitors and inducers in the Sentinel Distributed Database (SDD). Data from January 1, 2013 to December 31, 2016 from 16 health plans contributing to the SDD were included in this report. This request was distributed on June 2, 2017.

Additional Details
FDA Center
CDER
Time Period
January 1, 2013 - December 31, 2016
Study Type
Modular Program
Assessment Type
Safety Analyses
Population / Cohort
All individuals
Data Sources
Sentinel Distributed Database (SDD)